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海峡生命科学前沿论坛第八十七讲(2018.3.20)-Cross-species genetic mapping of targets in aging and metabolism


海峡联合研究院   发布时间: 2018-03-12  信息员:  

时       间:2018年320号  下午14:30-15:30

地       点:林学中心会议室301

主办单位:园艺中心

报告题目:Cross-species genetic mapping of targets in aging and metabolism

报  告  人:Xu Wang

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne


简     介:  

Identifying the genetic and environmental factors that impact on complex traits and how they influence the development of common diseases is a challenge and priority in biomedical research. We developed a series of systems approaches, including (expression-based) phenome-wide association, transcriptome-/proteome-wide association, mediation analysis. Applied to multi-omics datasets from a mouse genetic reference population, we were able to identify and validate many novel links between genes and clinical/molecular phenotypes, such as longevity, body weight, lipid metabolism, and mitochondrial respiration. Importantly, unlike many links seen in classical loss-of-function mouse studies, the gene-phenotype links identified in population studies were robust and translated well across species e.g. human, mice, worms, and plants. Our multilayered integrative approaches, have been implemented on an open-access web server (www.systems-genetics.org), hence expediting and consolidating the systems dissection of gene function.